王祥瑞主任醫師
上海交通大學醫學院附屬仁濟醫院麻醉科
職 稱：主任醫師 職 務：疼痛科主任 院 區：東院，南院 科 室：麻醉科 醫療專長：研究及擅長心血管手術麻醉管理，圍術期液體治療，臨床監測，危重疾病診治以及疼痛治療。在疼痛治療方面采用各種微創神經介入技術，椎間孔鏡微創手術治療椎間盤突出癥，神經毀損治療頑固性癌痛和帶狀皰疹后遺神經痛，腰 門診時間：東院 每周一上午 南院 每周三上午 教育經歷 1982年獲醫學學士學位，1990年獲麻醉學碩士學位，1995年獲藥理學博士學位。 學術職務 中國醫師學會麻醉分會常委，中華醫學會疼痛分會全國委員，中華針灸學會針刺麻醉理事會副主任委員，中醫藥促進會軟組織疼痛分會副主任委員，中華醫學會麻醉學分會委員會委員，上海醫學會麻醉學會副主任委員，上海醫學會危重病學會委員，上海醫學會疼痛專業委員會主任委員，上海針灸學會針刺麻醉分會副主任委員 論文著作 1、 A preliminary study on the monitoring of mixed venous oxygen saturation through the left main bronchus. Critical Care 2006, 10:R7-R13 Hypoxia upregulates hypoxia inducible factor (HIF)-3alpha expression in lung epithelial cells: characterization and comparison with HIF-1alpha. Cell Res. 2006 Jun;16(6):548-58 3、Low hematocrit worsens cerebral injury after prolonged hypothermic circulatory arrest in rats. CAN J ANESTH 2006 , 53( 12 ): 1220–1229 4、Up-regulation of Hypoxia Inducible Factor 1alpha by Isoflurane in Hep3B Cells. Anesthesiology. 2006 Dec;105(6):1211-1219 5、Activations of mitogen-activated protein kinase and nuclear factor-kappaB by mechanical stretch result in ventilation-induced lung injury. 2007;68:356-360 Med Hypotheses. 6、Response of Alveolar Type II Epithelial Cells to Mechanical Stretch and Lipopolysaccharide. 2007;74(5):579-85 Respiration 7、Dose-dependent neuroprotection of delta opioid peptide [D-Ala2, D-Leu5] enkephalin in neuronal death and retarded behavior induced by forebrain ischemia in rats. 2007;423(2):113-7 Neurosci Lett. 8、Role of Rel A and IkappaB of nuclear factor kappaB in the release of interleukin-8 by cyclic mechanical strain in human alveolar type II epithelial cells A549. 2007 Nov;12(6):792-8 Respirology. 9、Attenuating phosphorylation of p38 MAPK in the activated microglia: a new mechanism for intrathecal lidocaine reversing tactile allodynia following chronic constriction injury in rats. 2008Jan 31;431(2):129-34. Neurosci Lett 10、Delta opioid agonist [D-Ala2, D-Leu5] enkephalin (DADLE) reduced oxygen-glucose deprivation caused neuronal injury through the MAPK pathway. Brain Res.2009Oct 6;1292:100-106. 11、In reply to ‘‘Is intrathecal lidocaine administration risk-free in rats with neuropathic pain?” Eur J Pain.2009, 13(6):891 12、Effects of intrathecal lidocaine on hyperalgesia and allodynia following chronic constriction injury in rats. Eur J Pain.2009 Feb;13(2):130-137 13、Activity of sulfotransferase 1A1 is dramatically upregulated in patients with hepatocellular carcinoma secondary to chronic hepatitis B virus infection. Cancer Sci.2010 Feb;101(2):412-415 14、Resection of the nerves bundle from the sphenopalatine ganglia tend to increase the infarction volume following middle cerebral artery occlusion. Neurol Sci.2010 Aug;31(4):431-435 15、Lidocaine attenuates proinflammatory cytokine production induced by extracellular adenosine triphosphate in cultured rat microglia. Anesth Analg. 2010 Sep;111(3):768-774 16、Time course of action and pharmacokinetics of ropivacaine in adult and elderly patients following combined lumbar plexus-sciatic nerve block. Int J Clin Pharmacol Ther.2010 Sep;48(9):608-613 17、Repeated but not single isoflurane exposure improved the spatial memory of young adult mice.. Acta Anaesthesiol Scand,2011;55(4):468-473. 18、Delta opioid peptide [d-Ala2, d-Leu5] enkephalin (DADLE) triggers postconditioning against transient forebrain ischemia.. Eur J Pharmacol,2011;658(2-3):140-144. 19、Hydroxyethyl Starch (130 kD) Inhibits Toll-Like Receptor 4 Signaling Pathways in Rat Lungs Challenged with Lipopolysaccharide.. Anesth Analg,2011;113(1):112-119 20、Isoflurane-induced spatial memory impairment in mice is prevented by the acetylcholinesterase inhibitor donepezil.. PLoS One.,2011;6(11):e27632. 21、Decreased hepatic peroxisome proliferator-activated receptor-γ contributes to increased sensitivity to endotoxin in obstructive jaundice.. World J Gastroenterol.,2011;17(48):5267-5273. 22、Isoflurane Exposure during Mid-Adulthood Attenuates Age-Related Spatial Memory Impairment in APP/PS1 Transgenic Mice. PLoS One.,2012;7(11):e50172. 23、Phenacetin O-deethylation is a useful tool for evaluation of hepatic functional reserve in rats with CCl(4)-induced chronic liver injury.. J Surg Res.,2012;175(2):e61-66. 24、Protective Effects of the Delta Opioid Peptide [D-Ala2, D-Leu5]enkephalin in an Ex Vivo Model of Ischemia/Reperfusion in Brain Slices.. CNS Neurosci Ther.,2012;18(9):762-766. 25、Changes in pressure pain thresholds and Basal electromyographic activity after instrument-assisted spinal manipulative therapy in asymptomatic participants: a randomized, controlled trial.. J Manipulative Physiol Ther.,2012;35(6):437-445. 26、Electroacupuncture improves survival in rats with lethal endotoxemia via the autonomic nervous system.. Anesthesiology.,2012;116(2):406-414 27、Lipopolysaccharide Induces Lung Fibroblast Proliferation through Toll-Like Receptor 4 Signaling and the Phosphoinositide3-Kinase-Akt Pathway.. PLoS ONE,2012;7(4):e35926 28、Isoflurane Prevents Neurocognitive Dysfunction After Cardiopulmonary Bypass in Rats.. J Cardiothorac Vasc Anesth.,2013 Jun;27(3):502-9. 29、Epigenetic regulation of Thy-1 gene expression by histone modification is involved in lipopolysaccharide-induced lung fibroblast proliferation.J Cell Mol Med. 2013 Jan;17(1):160-7. 30. TLR4 as receptor for HMGB1-mediated acute lung injury after liver ischemia/reperfusion injury. Lab Invest, 2013 Jul;93(7):792-800. 31. Toll-like receptor 4 mediates acute lung injury induced by high mobility group box-1. PLoS One, 2013 May 17;8(5):e64375. 32. Smaller Sized Inhaled Anesthetics have More Potency on Senescence-Accelerated Prone-8 Mice Compared with Senescence-Resistant-1 Mice. J Alzheimers Dis, 2013 Oct. 創新專利實用新型專利： 支氣管內環境微型無創壓力溫度監測裝置 氣管插管牙齒保護套 經氣道無創監測混合靜脈血氧飽和度氣管導管 支氣管內環境微型無創pH值監測裝置 電針調控人體循環生物信息伺服裝置 針刺鎮痛生物信息整合與反饋裝置 人體疼痛生物信息多參數整合即時評估裝置 呼吸道高壓氧氣噴射給藥裝置 獲得榮譽2006年，針麻心臟手術心肺保護作用及機制研究，獲中國針灸學會(二等獎); 2006年，復合針刺技術對圍術期缺血心肌保護作用及其機制研究，獲上海市醫學獎(三等獎); 2008年，手術病人循環功能調控新策略，獲上海市科技進步獎(三等獎); 2009年，低氧耐受及呼吸道壓力生物學效應與術后肺部并發癥; 2009年，上海市育才獎
心血管手術麻醉管理，圍術期液體治療，臨床監測，危重疾病診治以及疼痛治療。?
